Endocannabinoid turnover in GtoPdb v.2023.1

The principle endocannabinoids are 2-acylglycerol esters, such as 2-arachidonoylglycerol (2-AG), and N-acylethanolamines, anandamide (N-arachidonoylethanolamine, AEA). glycerol esters ethanolamides synthesised hydrolysed by parallel, independent pathways. Mechanisms for release re-uptake of unclear, although potent selective inhibitors facilitated diffusion across cell membranes have been developed [29]. FABP5 (Q01469) has suggested to act a canonical intracellular endocannabinoid transporter in vivo [17]. For the generation 2-arachidonoylglycerol, key enzyme involved is diacylglycerol lipase (DAGL), whilst several routes synthesis described, best characterized which involves N-acylphosphatidylethanolamine-phospholipase D (NAPE-PLD, [75]). A transacylation forms N-acylphosphatidylethanolamines identified cytosolic enzyme, PLA2G4E (Q3MJ16) [66]. In vitro experiments indicate that also substrates oxidative metabolism via cyclooxygenase, lipoxygenase cytochrome P450 activities [5, 24, 77].